Drug interactions
Prochlorperazine + Risperidone
Severity: Major
Prochlorperazine and Risperidone: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concurrent antipsychotics raise the risk of extrapyramidal symptoms, neuroleptic malignant syndrome, sedation and QT prolongation. The QT effect can lead to torsades de pointes in susceptible patients.
What this interaction means in plain words
Prochlorperazine and Risperidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Prochlorperazine belongs to Central Nervous System; Risperidone belongs to Central Nervous System.
Why it happens
Additive dopamine D2 blockade and additive prolongation of cardiac repolarization.
What to do
Avoid the combination where possible, or use the lowest prochlorperazine dose for the shortest time. Monitor ECG, electrolytes and movement disorders.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Prochlorperazine with Risperidone?
MediHelp rates the interaction as major. Prochlorperazine and Risperidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Concurrent antipsychotics raise the risk of extrapyramidal symptoms, neuroleptic malignant syndrome, sedation and QT prolongation. The QT effect can lead to torsades de pointes in susceptible patients.
How serious is the interaction between Prochlorperazine and Risperidone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or use the lowest prochlorperazine dose for the shortest time. Monitor ECG, electrolytes and movement disorders.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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