Drug interactions
Prochlorperazine + Sevoflurane
Severity: Moderate
Prochlorperazine and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prochlorperazine adds to the central depressant effect of volatile anesthetics and can deepen sedation or cause hypotension during and after anesthesia. Both agents may also prolong the QT interval, which matters in perioperative patients with electrolyte disturbances.
What this interaction means in plain words
Prochlorperazine and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Prochlorperazine belongs to Central Nervous System; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive CNS depression and alpha-adrenergic blockade from prochlorperazine, plus additive QT prolongation.
What to do
Inform the anesthesia team of recent phenothiazine use and titrate anesthetic depth to effect. Monitor ECG, blood pressure and electrolytes perioperatively.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Sevoflurane
Frequently asked questions
Can I take Prochlorperazine with Sevoflurane?
MediHelp rates the interaction as moderate. Prochlorperazine and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Prochlorperazine adds to the central depressant effect of volatile anesthetics and can deepen sedation or cause hypotension during and after anesthesia. Both agents may also prolong the QT interval, which matters in perioperative patients with electrolyte disturbances.
How serious is the interaction between Prochlorperazine and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team of recent phenothiazine use and titrate anesthetic depth to effect. Monitor ECG, blood pressure and electrolytes perioperatively.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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