Drug interactions
Prochlorperazine + Sotalol
Severity: Major
Prochlorperazine and Sotalol: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotalol prolongs the QT interval by itself, and prochlorperazine adds to this effect, increasing the risk of torsades de pointes. Risk is higher with hypokalemia, hypomagnesemia or bradycardia.
What this interaction means in plain words
Prochlorperazine and Sotalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Prochlorperazine belongs to Central Nervous System; Sotalol belongs to Cardiovascular.
Why it happens
Additive QT prolongation via potassium channel blockade.
What to do
Avoid the combination where possible and choose an antiemetic with less QT liability. If used, monitor ECG and keep potassium and magnesium within normal range.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Frequently asked questions
Can I take Prochlorperazine with Sotalol?
MediHelp rates the interaction as major. Prochlorperazine and Sotalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sotalol prolongs the QT interval by itself, and prochlorperazine adds to this effect, increasing the risk of torsades de pointes. Risk is higher with hypokalemia, hypomagnesemia or bradycardia.
How serious is the interaction between Prochlorperazine and Sotalol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and choose an antiemetic with less QT liability. If used, monitor ECG and keep potassium and magnesium within normal range.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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