Drug interactions
Prochlorperazine + Tiotropium-olodaterol
Severity: Moderate
Prochlorperazine and Tiotropium-olodaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prochlorperazine has anticholinergic properties that can add to tiotropium, increasing dry mouth, constipation, urinary retention and glaucoma risk. It also can prolong the QT interval, which olodaterol may compound.
What this interaction means in plain words
Prochlorperazine and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Prochlorperazine belongs to Central Nervous System; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Additive antimuscarinic effects and additive QT prolongation with beta2-mediated hypokalemia.
What to do
Monitor for anticholinergic effects such as urinary retention and eye pain. Check ECG and potassium if there are other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium-olodaterol
Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Frequently asked questions
Can I take Prochlorperazine with Tiotropium-olodaterol?
MediHelp rates the interaction as moderate. Prochlorperazine and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Prochlorperazine has anticholinergic properties that can add to tiotropium, increasing dry mouth, constipation, urinary retention and glaucoma risk. It also can prolong the QT interval, which olodaterol may compound.
How serious is the interaction between Prochlorperazine and Tiotropium-olodaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects such as urinary retention and eye pain. Check ECG and potassium if there are other QT risk factors.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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