Drug interactions
Prochlorperazine + Tramadol
Severity: Moderate
Prochlorperazine and Tramadol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, so together they increase sedation and may cause respiratory depression and hypotension. Both also lower the seizure threshold, so seizure risk may rise.
What this interaction means in plain words
Prochlorperazine and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Prochlorperazine belongs to Central Nervous System; Tramadol belongs to Musculoskeletal.
Why it happens
Additive CNS depression and additive lowering of seizure threshold.
What to do
Use the lowest effective doses and monitor sedation, respiratory status and seizure activity. Avoid alcohol and other sedatives.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Tramadol
- Isocarboxazid + Tramadol Contraindicated
- Olanzapine / samidorphan + Tramadol Contraindicated
- Phenelzine + Tramadol Contraindicated
- Procarbazine + Tramadol Contraindicated
- Rasagiline + Tramadol Contraindicated
- Safinamide + Tramadol Contraindicated
Frequently asked questions
Can I take Prochlorperazine with Tramadol?
MediHelp rates the interaction as moderate. Prochlorperazine and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, so together they increase sedation and may cause respiratory depression and hypotension. Both also lower the seizure threshold, so seizure risk may rise.
How serious is the interaction between Prochlorperazine and Tramadol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation, respiratory status and seizure activity. Avoid alcohol and other sedatives.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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