Drug interactions
Prochlorperazine + Valbenazine
Severity: Moderate
Prochlorperazine and Valbenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and valbenazine may increase this effect at higher exposures. Valbenazine also treats tardive dyskinesia, which may be caused by dopamine blockers such as prochlorperazine, and combined use may cause additive somnolence.
What this interaction means in plain words
Prochlorperazine and Valbenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Prochlorperazine belongs to Central Nervous System; Valbenazine belongs to Central Nervous System.
Why it happens
Additive QT prolongation and additive sedation through VMAT2 inhibition and dopamine blockade.
What to do
Obtain a baseline ECG and correct potassium and magnesium abnormalities in patients with QT risk factors. Monitor for somnolence and arrhythmia symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Valbenazine
- Deutetrabenazine + Valbenazine Contraindicated
- Tranylcypromine + Valbenazine Contraindicated
- Amiodarone + Valbenazine Major
- Amisulpride + Valbenazine Major
- Apalutamide + Valbenazine Major
- Carbamazepine + Valbenazine Major
Frequently asked questions
Can I take Prochlorperazine with Valbenazine?
MediHelp rates the interaction as moderate. Prochlorperazine and Valbenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, and valbenazine may increase this effect at higher exposures. Valbenazine also treats tardive dyskinesia, which may be caused by dopamine blockers such as prochlorperazine, and combined use may cause additive somnolence.
How serious is the interaction between Prochlorperazine and Valbenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium abnormalities in patients with QT risk factors. Monitor for somnolence and arrhythmia symptoms.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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