Drug interactions
Progesterone + Rucaparib
Severity: Minor
Progesterone and Rucaparib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib inhibits CYP3A4 weakly and may increase progesterone exposure. Clinical significance is likely small.
What this interaction means in plain words
Progesterone and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Progesterone belongs to Endocrine; Rucaparib belongs to Oncology.
Why it happens
Rucaparib weakly inhibits CYP3A4, reducing progesterone metabolism.
What to do
No routine adjustment needed; monitor for progestogenic adverse effects such as sedation or bloating and reduce the dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Progesterone
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Progesterone with Rucaparib?
MediHelp rates the interaction as minor. Progesterone and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib inhibits CYP3A4 weakly and may increase progesterone exposure. Clinical significance is likely small.
How serious is the interaction between Progesterone and Rucaparib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment needed; monitor for progestogenic adverse effects such as sedation or bloating and reduce the dose if they occur.
What other medicines interact with Progesterone?
MediHelp also lists interactions of Progesterone with, for example, Apalutamide, Carbamazepine, Enzalutamide. The full list is on the Progesterone page.
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