Drug interactions
Progesterone + Stiripentol
Severity: Moderate
Progesterone and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol has both inhibitory and inducing effects on CYP3A4, so progesterone exposure may rise or fall unpredictably. Efficacy or adverse effects may change.
What this interaction means in plain words
Progesterone and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Progesterone belongs to Endocrine; Stiripentol belongs to Central Nervous System.
Why it happens
Stiripentol modulates CYP3A4 activity through mixed inhibition and induction.
What to do
Monitor for loss of hormonal effect or excess progestogenic effects and adjust the progesterone dose accordingly. Use a non-hormonal contraceptive back-up if contraception is required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Progesterone
Other interactions of Stiripentol
Frequently asked questions
Can I take Progesterone with Stiripentol?
MediHelp rates the interaction as moderate. Progesterone and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol has both inhibitory and inducing effects on CYP3A4, so progesterone exposure may rise or fall unpredictably. Efficacy or adverse effects may change.
How serious is the interaction between Progesterone and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of hormonal effect or excess progestogenic effects and adjust the progesterone dose accordingly. Use a non-hormonal contraceptive back-up if contraception is required.
What other medicines interact with Progesterone?
MediHelp also lists interactions of Progesterone with, for example, Apalutamide, Carbamazepine, Enzalutamide. The full list is on the Progesterone page.
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