Drug interactions
Propofol + Risperidone
Severity: Moderate
Propofol and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propofol is a potent sedative-hypnotic, and risperidone may enhance its sedative and hypotensive effects. Both can also prolong the QT interval modestly.
What this interaction means in plain words
Propofol and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Propofol belongs to Central Nervous System; Risperidone belongs to Central Nervous System.
Why it happens
Additive CNS depression, hypotension from alpha-1 blockade, and additive QT effects.
What to do
Titrate propofol cautiously and monitor blood pressure, airway and ECG during anesthesia or sedation. Lower doses may be sufficient.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Other interactions of Propofol
Frequently asked questions
Can I take Propofol with Risperidone?
MediHelp rates the interaction as moderate. Propofol and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propofol is a potent sedative-hypnotic, and risperidone may enhance its sedative and hypotensive effects. Both can also prolong the QT interval modestly.
How serious is the interaction between Propofol and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate propofol cautiously and monitor blood pressure, airway and ECG during anesthesia or sedation. Lower doses may be sufficient.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
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