Drug interactions
Propofol + Sevoflurane
Severity: Moderate
Propofol and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propofol and sevoflurane together deepen anesthesia and reduce the dose requirement of each agent. Both cause dose-dependent hypotension and respiratory depression, which are intensified when combined.
What this interaction means in plain words
Propofol and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Propofol belongs to Central Nervous System; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive GABA-A receptor potentiation and cardiovascular depression.
What to do
Reduce doses of each agent and titrate to anesthetic depth monitoring. Monitor blood pressure and ventilation continuously.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sevoflurane
Other interactions of Propofol
Frequently asked questions
Can I take Propofol with Sevoflurane?
MediHelp rates the interaction as moderate. Propofol and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propofol and sevoflurane together deepen anesthesia and reduce the dose requirement of each agent. Both cause dose-dependent hypotension and respiratory depression, which are intensified when combined.
How serious is the interaction between Propofol and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce doses of each agent and titrate to anesthetic depth monitoring. Monitor blood pressure and ventilation continuously.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Sevoflurane page.
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