Drug interactions
Propofol + Sotalol
Severity: Moderate
Propofol and Sotalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propofol causes vasodilation and myocardial depression, and sotalol limits the compensatory heart rate and contractile response. The combination can produce pronounced hypotension and bradycardia during anesthesia or sedation.
What this interaction means in plain words
Propofol and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Propofol belongs to Central Nervous System; Sotalol belongs to Cardiovascular.
Why it happens
Additive cardiovascular depression: propofol vasodilation and negative inotropy with beta-blocker suppression of compensatory responses.
What to do
Titrate propofol slowly and monitor blood pressure, heart rate and ECG continuously. Have fluids and vasopressors or anticholinergics available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Other interactions of Propofol
Frequently asked questions
Can I take Propofol with Sotalol?
MediHelp rates the interaction as moderate. Propofol and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propofol causes vasodilation and myocardial depression, and sotalol limits the compensatory heart rate and contractile response. The combination can produce pronounced hypotension and bradycardia during anesthesia or sedation.
How serious is the interaction between Propofol and Sotalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate propofol slowly and monitor blood pressure, heart rate and ECG continuously. Have fluids and vasopressors or anticholinergics available.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
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