Drug interactions
Propofol + Stiripentol
Severity: Moderate
Propofol and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol causes sedation and somnolence, which can add to the anesthetic and sedative effects of propofol. Stiripentol also affects CYP2B6, which contributes to propofol metabolism, so propofol exposure may shift unpredictably.
What this interaction means in plain words
Propofol and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Propofol belongs to Central Nervous System; Stiripentol belongs to Central Nervous System.
Why it happens
Additive CNS depression plus mixed inhibition and induction of CYP2B6 by stiripentol, which may alter propofol clearance.
What to do
Titrate propofol to clinical effect with careful monitoring of sedation depth, and expect that dose requirements may differ from usual. Watch respiratory and hemodynamic status during and after the procedure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Propofol and Stiripentol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Propofol
Other interactions of Stiripentol
Frequently asked questions
Can I take Propofol with Stiripentol?
MediHelp rates the interaction as moderate. Propofol and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol causes sedation and somnolence, which can add to the anesthetic and sedative effects of propofol. Stiripentol also affects CYP2B6, which contributes to propofol metabolism, so propofol exposure may shift unpredictably.
How serious is the interaction between Propofol and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate propofol to clinical effect with careful monitoring of sedation depth, and expect that dose requirements may differ from usual. Watch respiratory and hemodynamic status during and after the procedure.
What other medicines interact with Propofol?
MediHelp also lists interactions of Propofol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Propofol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
