Drug interactions
Propofol + Tramadol
Severity: Moderate
Propofol and Tramadol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propofol and opioids together produce deeper sedation and greater respiratory and cardiovascular depression than either alone. This is often intended in anesthesia but needs careful dosing.
What this interaction means in plain words
Propofol and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Propofol belongs to Central Nervous System; Tramadol belongs to Musculoskeletal.
Why it happens
Additive CNS, respiratory and hemodynamic depression.
What to do
Titrate propofol to effect with continuous monitoring of oxygenation, ventilation and blood pressure. Reduce doses in elderly or frail patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tramadol
- Isocarboxazid + Tramadol Contraindicated
- Olanzapine / samidorphan + Tramadol Contraindicated
- Phenelzine + Tramadol Contraindicated
- Procarbazine + Tramadol Contraindicated
- Rasagiline + Tramadol Contraindicated
- Safinamide + Tramadol Contraindicated
Other interactions of Propofol
Frequently asked questions
Can I take Propofol with Tramadol?
MediHelp rates the interaction as moderate. Propofol and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propofol and opioids together produce deeper sedation and greater respiratory and cardiovascular depression than either alone. This is often intended in anesthesia but needs careful dosing.
How serious is the interaction between Propofol and Tramadol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate propofol to effect with continuous monitoring of oxygenation, ventilation and blood pressure. Reduce doses in elderly or frail patients.
What other medicines interact with Tramadol?
MediHelp also lists interactions of Tramadol with, for example, Isocarboxazid, Olanzapine / samidorphan, Phenelzine. The full list is on the Tramadol page.
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