Drug interactions
Propofol + Trazodone
Severity: Moderate
Propofol and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propofol is a potent sedative-hypnotic and trazodone adds sedative and hypotensive effects. Anesthetic requirements and the risk of hypotension may be affected during procedures.
What this interaction means in plain words
Propofol and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Propofol belongs to Central Nervous System; Trazodone belongs to Central Nervous System.
Why it happens
Additive CNS depression and vasodilation or alpha-1 blockade.
What to do
Inform the anesthesia team of trazodone use and titrate propofol to effect with continuous hemodynamic monitoring. Be ready to treat hypotension.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Propofol
Frequently asked questions
Can I take Propofol with Trazodone?
MediHelp rates the interaction as moderate. Propofol and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propofol is a potent sedative-hypnotic and trazodone adds sedative and hypotensive effects. Anesthetic requirements and the risk of hypotension may be affected during procedures.
How serious is the interaction between Propofol and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team of trazodone use and titrate propofol to effect with continuous hemodynamic monitoring. Be ready to treat hypotension.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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