Drug interactions
Ranolazine + Talazoparib
Severity: Moderate
Ranolazine and Talazoparib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Talazoparib is a P-gp substrate, and ranolazine is a weak P-gp inhibitor that may increase talazoparib exposure. This could increase hematologic toxicity such as anemia and thrombocytopenia.
What this interaction means in plain words
Ranolazine and Talazoparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ranolazine belongs to Cardiovascular; Talazoparib belongs to Oncology.
Why it happens
Inhibition of P-gp efflux by ranolazine, increasing talazoparib absorption and reducing its clearance.
What to do
Monitor blood counts closely. Reduce the talazoparib dose per labeling if hematologic toxicity develops, or consider an alternative to ranolazine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Talazoparib
- Carvedilol + Talazoparib Major
- Itraconazole + Talazoparib Major
- Amiodarone + Talazoparib Moderate
- Azithromycin + Talazoparib Moderate
- Clarithromycin + Talazoparib Moderate
- Cyclosporin + Talazoparib Moderate
Frequently asked questions
Can I take Ranolazine with Talazoparib?
MediHelp rates the interaction as moderate. Ranolazine and Talazoparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Talazoparib is a P-gp substrate, and ranolazine is a weak P-gp inhibitor that may increase talazoparib exposure. This could increase hematologic toxicity such as anemia and thrombocytopenia.
How serious is the interaction between Ranolazine and Talazoparib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts closely. Reduce the talazoparib dose per labeling if hematologic toxicity develops, or consider an alternative to ranolazine.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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