Drug interactions
Ranolazine + Vilazodone
Severity: Minor
Ranolazine and Vilazodone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ranolazine is a weak CYP3A4 inhibitor and may slightly raise vilazodone concentrations. The increase is expected to be small and is unlikely to be clinically significant in most patients.
What this interaction means in plain words
Ranolazine and Vilazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ranolazine belongs to Cardiovascular; Vilazodone belongs to Central Nervous System.
Why it happens
Weak inhibition of CYP3A4 by ranolazine reduces vilazodone metabolism.
What to do
No dose adjustment is usually needed. Watch for serotonergic or gastrointestinal adverse effects after starting ranolazine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Frequently asked questions
Can I take Ranolazine with Vilazodone?
MediHelp rates the interaction as minor. Ranolazine and Vilazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ranolazine is a weak CYP3A4 inhibitor and may slightly raise vilazodone concentrations. The increase is expected to be small and is unlikely to be clinically significant in most patients.
How serious is the interaction between Ranolazine and Vilazodone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed. Watch for serotonergic or gastrointestinal adverse effects after starting ranolazine.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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