Drug interactions
Ribociclib + Rolapitant
Severity: Minor
Ribociclib and Rolapitant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib is a moderate CYP3A4 inhibitor, so it could raise rolapitant levels. Rolapitant has a wide margin of safety and is used in short courses. Ribociclib itself prolongs the QT interval, but rolapitant is not known to do so.
What this interaction means in plain words
Ribociclib and Rolapitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ribociclib belongs to Oncology; Rolapitant belongs to Gastrointestinal Tract.
Why it happens
Ribociclib inhibits CYP3A4, which contributes to rolapitant metabolism.
What to do
No dose adjustment is usually required. Monitor for rolapitant adverse effects such as fatigue or headache.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rolapitant
- Pimozide + Rolapitant Contraindicated
- Rolapitant + Thioridazine Contraindicated
- Atomoxetine + Rolapitant Major
- Deutetrabenazine + Rolapitant Major
- Eliglustat + Rolapitant Major
- Flecainide + Rolapitant Major
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Ribociclib with Rolapitant?
MediHelp rates the interaction as minor. Ribociclib and Rolapitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ribociclib is a moderate CYP3A4 inhibitor, so it could raise rolapitant levels. Rolapitant has a wide margin of safety and is used in short courses. Ribociclib itself prolongs the QT interval, but rolapitant is not known to do so.
How serious is the interaction between Ribociclib and Rolapitant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually required. Monitor for rolapitant adverse effects such as fatigue or headache.
What other medicines interact with Rolapitant?
MediHelp also lists interactions of Rolapitant with, for example, Pimozide, Thioridazine, Atomoxetine. The full list is on the Rolapitant page.
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