Drug interactions
Riluzole + Stiripentol
Severity: Moderate
Riluzole and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol has both inhibitory and inducing effects on CYP1A2, so riluzole exposure may rise or fall. This makes its efficacy and safety less predictable.
What this interaction means in plain words
Riluzole and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Riluzole belongs to Miscellaneous; Stiripentol belongs to Central Nervous System.
Why it happens
Mixed CYP1A2 inhibition and induction by stiripentol alters riluzole clearance.
What to do
Monitor clinical response and liver enzymes when stiripentol is started, changed or stopped. Adjust riluzole dosing according to tolerability and response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Riluzole
- Fluvoxamine + Riluzole Major
- Cannabidiol + Riluzole Moderate
- Ciprofloxacin + Riluzole Moderate
- Elranatamab + Riluzole Moderate
- Epcoritamab + Riluzole Moderate
- Fexinidazole + Riluzole Moderate
Other interactions of Stiripentol
Frequently asked questions
Can I take Riluzole with Stiripentol?
MediHelp rates the interaction as moderate. Riluzole and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol has both inhibitory and inducing effects on CYP1A2, so riluzole exposure may rise or fall. This makes its efficacy and safety less predictable.
How serious is the interaction between Riluzole and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and liver enzymes when stiripentol is started, changed or stopped. Adjust riluzole dosing according to tolerability and response.
What other medicines interact with Riluzole?
MediHelp also lists interactions of Riluzole with, for example, Fluvoxamine, Cannabidiol, Ciprofloxacin. The full list is on the Riluzole page.
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