Drug interactions
Riluzole + Zileuton
Severity: Moderate
Riluzole and Zileuton: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Riluzole is mainly metabolized by CYP1A2, so zileuton may increase riluzole exposure. This could heighten dose-related adverse effects such as nausea, fatigue and liver enzyme elevation; both drugs can also affect the liver.
What this interaction means in plain words
Riluzole and Zileuton can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Riluzole belongs to Miscellaneous; Zileuton belongs to Respiratory.
Why it happens
Zileuton inhibits CYP1A2, the major enzyme in riluzole clearance.
What to do
Monitor liver aminotransferases more frequently and watch for riluzole toxicity. Consider an alternative to zileuton if hepatic tests rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zileuton
- Fezolinetant + Zileuton Contraindicated
- Pimozide + Zileuton Contraindicated
- Alosetron + Zileuton Major
- Clozapine + Zileuton Major
- Lomitapide + Zileuton Major
- Lonafarnib + Zileuton Major
Other interactions of Riluzole
- Fluvoxamine + Riluzole Major
- Cannabidiol + Riluzole Moderate
- Ciprofloxacin + Riluzole Moderate
- Elranatamab + Riluzole Moderate
- Epcoritamab + Riluzole Moderate
- Fexinidazole + Riluzole Moderate
Frequently asked questions
Can I take Riluzole with Zileuton?
MediHelp rates the interaction as moderate. Riluzole and Zileuton can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Riluzole is mainly metabolized by CYP1A2, so zileuton may increase riluzole exposure. This could heighten dose-related adverse effects such as nausea, fatigue and liver enzyme elevation; both drugs can also affect the liver.
How serious is the interaction between Riluzole and Zileuton?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver aminotransferases more frequently and watch for riluzole toxicity. Consider an alternative to zileuton if hepatic tests rise.
What other medicines interact with Zileuton?
MediHelp also lists interactions of Zileuton with, for example, Fezolinetant, Pimozide, Alosetron. The full list is on the Zileuton page.
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