Drug interactions
Rimegepant + Rolapitant
Severity: Moderate
Rimegepant and Rolapitant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rolapitant inhibits P-glycoprotein and may increase rimegepant exposure. Higher levels could increase adverse effects such as nausea and hypersensitivity reactions.
What this interaction means in plain words
Rimegepant and Rolapitant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rimegepant belongs to Central Nervous System; Rolapitant belongs to Gastrointestinal Tract.
Why it happens
Rolapitant inhibits intestinal P-glycoprotein efflux of rimegepant, increasing its absorption.
What to do
Avoid taking another rimegepant dose within 48 hours of a second dose if the combination is used. Monitor for adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rolapitant
- Pimozide + Rolapitant Contraindicated
- Rolapitant + Thioridazine Contraindicated
- Atomoxetine + Rolapitant Major
- Deutetrabenazine + Rolapitant Major
- Eliglustat + Rolapitant Major
- Flecainide + Rolapitant Major
Other interactions of Rimegepant
Frequently asked questions
Can I take Rimegepant with Rolapitant?
MediHelp rates the interaction as moderate. Rimegepant and Rolapitant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rolapitant inhibits P-glycoprotein and may increase rimegepant exposure. Higher levels could increase adverse effects such as nausea and hypersensitivity reactions.
How serious is the interaction between Rimegepant and Rolapitant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid taking another rimegepant dose within 48 hours of a second dose if the combination is used. Monitor for adverse effects.
What other medicines interact with Rolapitant?
MediHelp also lists interactions of Rolapitant with, for example, Pimozide, Thioridazine, Atomoxetine. The full list is on the Rolapitant page.
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