Drug interactions
Risperidone + Tepotinib
Severity: Moderate
Risperidone and Tepotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tepotinib inhibits P-glycoprotein, which may increase systemic exposure to risperidone and its active metabolite. This could heighten dose-related adverse effects such as sedation, extrapyramidal symptoms and orthostatic hypotension.
What this interaction means in plain words
Risperidone and Tepotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Risperidone belongs to Central Nervous System; Tepotinib belongs to Oncology.
Why it happens
Inhibition of P-glycoprotein efflux by tepotinib, increasing risperidone exposure.
What to do
Monitor for extrapyramidal symptoms, sedation and hypotension, and reduce the risperidone dose if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Other interactions of Tepotinib
- Colchicine + Tepotinib Major
- Digoxin + Tepotinib Major
- Tepotinib + Vincristine Major
- Amiodarone + Tepotinib Moderate
- Apixaban + Tepotinib Moderate
- Atorvastatin + Tepotinib Moderate
Frequently asked questions
Can I take Risperidone with Tepotinib?
MediHelp rates the interaction as moderate. Risperidone and Tepotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tepotinib inhibits P-glycoprotein, which may increase systemic exposure to risperidone and its active metabolite. This could heighten dose-related adverse effects such as sedation, extrapyramidal symptoms and orthostatic hypotension.
How serious is the interaction between Risperidone and Tepotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for extrapyramidal symptoms, sedation and hypotension, and reduce the risperidone dose if adverse effects appear.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
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