Drug interactions
Rolapitant + Rosuvastatin
Severity: Moderate
Rolapitant and Rosuvastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rolapitant inhibits BCRP, a transporter involved in rosuvastatin absorption and elimination. Rosuvastatin exposure increases substantially, which raises the risk of myopathy and rhabdomyolysis.
What this interaction means in plain words
Rolapitant and Rosuvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rolapitant belongs to Gastrointestinal Tract; Rosuvastatin belongs to Cardiovascular.
Why it happens
Rolapitant inhibits intestinal and hepatic BCRP, increasing rosuvastatin systemic exposure.
What to do
Use the lowest effective rosuvastatin dose during rolapitant use. Counsel patients to report muscle pain or weakness and monitor CK if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rolapitant
- Pimozide + Rolapitant Contraindicated
- Rolapitant + Thioridazine Contraindicated
- Atomoxetine + Rolapitant Major
- Deutetrabenazine + Rolapitant Major
- Eliglustat + Rolapitant Major
- Flecainide + Rolapitant Major
Other interactions of Rosuvastatin
Frequently asked questions
Can I take Rolapitant with Rosuvastatin?
MediHelp rates the interaction as moderate. Rolapitant and Rosuvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rolapitant inhibits BCRP, a transporter involved in rosuvastatin absorption and elimination. Rosuvastatin exposure increases substantially, which raises the risk of myopathy and rhabdomyolysis.
How serious is the interaction between Rolapitant and Rosuvastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective rosuvastatin dose during rolapitant use. Counsel patients to report muscle pain or weakness and monitor CK if symptoms occur.
What other medicines interact with Rolapitant?
MediHelp also lists interactions of Rolapitant with, for example, Pimozide, Thioridazine, Atomoxetine. The full list is on the Rolapitant page.
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