Drug interactions
Rolapitant + Sirolimus
Severity: Moderate
Rolapitant and Sirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral rolapitant inhibits intestinal P-glycoprotein and may raise exposure to sirolimus, a P-gp substrate with a narrow therapeutic window. Higher sirolimus levels can increase immunosuppression, hyperlipidemia, and other dose-related toxicities.
What this interaction means in plain words
Rolapitant and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rolapitant belongs to Gastrointestinal Tract; Sirolimus belongs to Miscellaneous.
Why it happens
Rolapitant inhibits P-glycoprotein efflux, increasing absorption and reducing clearance of sirolimus.
What to do
Monitor sirolimus trough concentrations and signs of toxicity if rolapitant is given. Adjust the sirolimus dose according to levels.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rolapitant
- Pimozide + Rolapitant Contraindicated
- Rolapitant + Thioridazine Contraindicated
- Atomoxetine + Rolapitant Major
- Deutetrabenazine + Rolapitant Major
- Eliglustat + Rolapitant Major
- Flecainide + Rolapitant Major
Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Rolapitant with Sirolimus?
MediHelp rates the interaction as moderate. Rolapitant and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral rolapitant inhibits intestinal P-glycoprotein and may raise exposure to sirolimus, a P-gp substrate with a narrow therapeutic window. Higher sirolimus levels can increase immunosuppression, hyperlipidemia, and other dose-related toxicities.
How serious is the interaction between Rolapitant and Sirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sirolimus trough concentrations and signs of toxicity if rolapitant is given. Adjust the sirolimus dose according to levels.
What other medicines interact with Rolapitant?
MediHelp also lists interactions of Rolapitant with, for example, Pimozide, Thioridazine, Atomoxetine. The full list is on the Rolapitant page.
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