Drug interactions
Rolapitant + Tazemetostat
Severity: Minor
Rolapitant and Tazemetostat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is a weak to moderate CYP3A4 inducer and may modestly lower rolapitant concentrations. Rolapitant is mainly given as a single dose for nausea prophylaxis, so the effect on antiemetic efficacy is likely small.
What this interaction means in plain words
Rolapitant and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Rolapitant belongs to Gastrointestinal Tract; Tazemetostat belongs to Miscellaneous.
Why it happens
Tazemetostat induces CYP3A4, increasing rolapitant metabolism.
What to do
No dose adjustment is needed. Watch for breakthrough nausea and add other antiemetics if it occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rolapitant
- Pimozide + Rolapitant Contraindicated
- Rolapitant + Thioridazine Contraindicated
- Atomoxetine + Rolapitant Major
- Deutetrabenazine + Rolapitant Major
- Eliglustat + Rolapitant Major
- Flecainide + Rolapitant Major
Other interactions of Tazemetostat
Frequently asked questions
Can I take Rolapitant with Tazemetostat?
MediHelp rates the interaction as minor. Rolapitant and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tazemetostat is a weak to moderate CYP3A4 inducer and may modestly lower rolapitant concentrations. Rolapitant is mainly given as a single dose for nausea prophylaxis, so the effect on antiemetic efficacy is likely small.
How serious is the interaction between Rolapitant and Tazemetostat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Watch for breakthrough nausea and add other antiemetics if it occurs.
What other medicines interact with Rolapitant?
MediHelp also lists interactions of Rolapitant with, for example, Pimozide, Thioridazine, Atomoxetine. The full list is on the Rolapitant page.
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