Drug interactions
Rucaparib + Ticlopidine
Severity: Minor
Rucaparib and Ticlopidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib is a weak inhibitor of CYP3A4 and CYP2C19, among others. Ticlopidine is not a sensitive substrate of CYP3A4, but it is activated through CYP2C19 and CYP2B6 pathways, so any change in exposure or effect is uncertain.
What this interaction means in plain words
Rucaparib and Ticlopidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Rucaparib belongs to Oncology; Ticlopidine belongs to Cardiovascular.
Why it happens
Possible weak inhibition of ticlopidine metabolism by rucaparib; not well characterized.
What to do
No routine adjustment is needed; monitor for ticlopidine adverse effects and blood counts as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Rucaparib and Ticlopidine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Ticlopidine
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Rucaparib with Ticlopidine?
MediHelp rates the interaction as minor. Rucaparib and Ticlopidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib is a weak inhibitor of CYP3A4 and CYP2C19, among others. Ticlopidine is not a sensitive substrate of CYP3A4, but it is activated through CYP2C19 and CYP2B6 pathways, so any change in exposure or effect is uncertain.
How serious is the interaction between Rucaparib and Ticlopidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor for ticlopidine adverse effects and blood counts as usual.
What other medicines interact with Ticlopidine?
MediHelp also lists interactions of Ticlopidine with, for example, Mavacamten, Abrocitinib, Acetylsalicylic acid. The full list is on the Ticlopidine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
