Drug interactions
Ruxolitinib + Tucatinib
Severity: Major
Ruxolitinib and Tucatinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib is a strong CYP3A inhibitor and can increase ruxolitinib concentrations. This may intensify hematologic toxicity such as thrombocytopenia and neutropenia.
What this interaction means in plain words
Ruxolitinib and Tucatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ruxolitinib belongs to Oncology; Tucatinib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated metabolism of ruxolitinib reduces its clearance.
What to do
If combined, lower the ruxolitinib dose per labeling for strong CYP3A4 inhibitors. Monitor blood counts and signs of infection closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ruxolitinib
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Ruxolitinib with Tucatinib?
MediHelp rates the interaction as major. Ruxolitinib and Tucatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tucatinib is a strong CYP3A inhibitor and can increase ruxolitinib concentrations. This may intensify hematologic toxicity such as thrombocytopenia and neutropenia.
How serious is the interaction between Ruxolitinib and Tucatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If combined, lower the ruxolitinib dose per labeling for strong CYP3A4 inhibitors. Monitor blood counts and signs of infection closely.
What other medicines interact with Ruxolitinib?
MediHelp also lists interactions of Ruxolitinib with, for example, Atazanavir, Ceritinib, Chloramphenicol. The full list is on the Ruxolitinib page.
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