Drug interactions
Silodosin + Tipranavir
Severity: Major
Silodosin and Tipranavir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir, usually given with ritonavir, is a strong CYP3A4 inhibitor and may markedly raise silodosin concentrations, increasing the risk of severe orthostatic hypotension and syncope. Strong CYP3A4 inhibitors are contraindicated with silodosin.
What this interaction means in plain words
Silodosin and Tipranavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Silodosin belongs to Genitourinary; Tipranavir belongs to Anti Virals.
Why it happens
Inhibition of CYP3A4 and P-glycoprotein reduces silodosin clearance.
What to do
Avoid the combination where possible; if unavoidable, use an alternative alpha-blocker and monitor blood pressure closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Silodosin
- Atazanavir + Silodosin Contraindicated
- Conivaptan + Silodosin Contraindicated
- Darunavir + Silodosin Contraindicated
- Fosamprenavir + Silodosin Contraindicated
- Indinavir + Silodosin Contraindicated
- Itraconazole + Silodosin Contraindicated
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Silodosin with Tipranavir?
MediHelp rates the interaction as major. Silodosin and Tipranavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tipranavir, usually given with ritonavir, is a strong CYP3A4 inhibitor and may markedly raise silodosin concentrations, increasing the risk of severe orthostatic hypotension and syncope. Strong CYP3A4 inhibitors are contraindicated with silodosin.
How serious is the interaction between Silodosin and Tipranavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if unavoidable, use an alternative alpha-blocker and monitor blood pressure closely.
What other medicines interact with Silodosin?
MediHelp also lists interactions of Silodosin with, for example, Atazanavir, Conivaptan, Darunavir. The full list is on the Silodosin page.
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