Drug interactions
Silodosin + Tizanidine
Severity: Moderate
Silodosin and Tizanidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs lower blood pressure, tizanidine through central alpha-2 agonism and silodosin through peripheral alpha-1A blockade. Combined use may cause additive hypotension, dizziness and sedation, particularly in older patients.
What this interaction means in plain words
Silodosin and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Silodosin belongs to Genitourinary; Tizanidine belongs to Musculoskeletal.
Why it happens
Additive hypotensive effects from central alpha-2 agonism and peripheral alpha-1 blockade.
What to do
Monitor blood pressure including standing readings when combining them, and start tizanidine at a low dose. Reduce the dose of one agent if dizziness or hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Silodosin
- Atazanavir + Silodosin Contraindicated
- Conivaptan + Silodosin Contraindicated
- Darunavir + Silodosin Contraindicated
- Fosamprenavir + Silodosin Contraindicated
- Indinavir + Silodosin Contraindicated
- Itraconazole + Silodosin Contraindicated
Other interactions of Tizanidine
- Ciprofloxacin + Tizanidine Contraindicated
- Fluvoxamine + Tizanidine Contraindicated
- Pefloxacin + Tizanidine Contraindicated
- Pipemidic acid + Tizanidine Contraindicated
- Benzhydrocodone / acetaminophen + Tizanidine Major
- Brexanolone + Tizanidine Major
Frequently asked questions
Can I take Silodosin with Tizanidine?
MediHelp rates the interaction as moderate. Silodosin and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs lower blood pressure, tizanidine through central alpha-2 agonism and silodosin through peripheral alpha-1A blockade. Combined use may cause additive hypotension, dizziness and sedation, particularly in older patients.
How serious is the interaction between Silodosin and Tizanidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure including standing readings when combining them, and start tizanidine at a low dose. Reduce the dose of one agent if dizziness or hypotension occurs.
What other medicines interact with Silodosin?
MediHelp also lists interactions of Silodosin with, for example, Atazanavir, Conivaptan, Darunavir. The full list is on the Silodosin page.
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