Drug interactions
Silodosin + Voriconazole
Severity: Contraindicated
Silodosin and Voriconazole: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole is a strong CYP3A4 inhibitor and is expected to raise silodosin concentrations substantially, increasing the risk of orthostatic hypotension and syncope. Strong CYP3A4 inhibitors are contraindicated with silodosin.
What this interaction means in plain words
Silodosin and Voriconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Silodosin belongs to Genitourinary; Voriconazole belongs to Anti Fungals.
Why it happens
Strong CYP3A4 inhibition reduces silodosin clearance.
What to do
Do not coadminister; withhold silodosin or use an alternative alpha-blocker during voriconazole therapy.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Silodosin
- Atazanavir + Silodosin Contraindicated
- Conivaptan + Silodosin Contraindicated
- Darunavir + Silodosin Contraindicated
- Fosamprenavir + Silodosin Contraindicated
- Indinavir + Silodosin Contraindicated
- Itraconazole + Silodosin Contraindicated
Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Silodosin with Voriconazole?
MediHelp rates the interaction as contraindicated. Silodosin and Voriconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Voriconazole is a strong CYP3A4 inhibitor and is expected to raise silodosin concentrations substantially, increasing the risk of orthostatic hypotension and syncope. Strong CYP3A4 inhibitors are contraindicated with silodosin.
How serious is the interaction between Silodosin and Voriconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; withhold silodosin or use an alternative alpha-blocker during voriconazole therapy.
What other medicines interact with Silodosin?
MediHelp also lists interactions of Silodosin with, for example, Atazanavir, Conivaptan, Darunavir. The full list is on the Silodosin page.
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