Drug interactions
Sofosbuvir + Tucatinib
Severity: Moderate
Sofosbuvir and Tucatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib inhibits intestinal P-glycoprotein and may raise exposure to sofosbuvir, a P-gp substrate. Higher levels of the prodrug could increase absorption of sofosbuvir, though the clinical effect of this is probably small because the active metabolite is formed intracellularly.
What this interaction means in plain words
Sofosbuvir and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sofosbuvir belongs to Anti Virals; Tucatinib belongs to Oncology.
Why it happens
Tucatinib inhibits P-glycoprotein efflux, increasing sofosbuvir absorption and systemic exposure.
What to do
Monitor for sofosbuvir adverse effects such as fatigue, headache and nausea during coadministration. No empirical dose change is established for sofosbuvir.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sofosbuvir
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Sofosbuvir with Tucatinib?
MediHelp rates the interaction as moderate. Sofosbuvir and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tucatinib inhibits intestinal P-glycoprotein and may raise exposure to sofosbuvir, a P-gp substrate. Higher levels of the prodrug could increase absorption of sofosbuvir, though the clinical effect of this is probably small because the active metabolite is formed intracellularly.
How serious is the interaction between Sofosbuvir and Tucatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sofosbuvir adverse effects such as fatigue, headache and nausea during coadministration. No empirical dose change is established for sofosbuvir.
What other medicines interact with Sofosbuvir?
MediHelp also lists interactions of Sofosbuvir with, for example, Amiodarone, Apalutamide, Carbamazepine. The full list is on the Sofosbuvir page.
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