Drug interactions
Stiripentol + Vilazodone
Severity: Moderate
Stiripentol and Vilazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol has both inhibitory and inducing effects on CYP3A4, so vilazodone exposure may rise or fall unpredictably. Both drugs can also cause somnolence, which may be additive.
What this interaction means in plain words
Stiripentol and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Stiripentol belongs to Central Nervous System; Vilazodone belongs to Central Nervous System.
Why it happens
Mixed CYP3A4 inhibition and induction by stiripentol alters vilazodone metabolism, plus additive CNS depression.
What to do
Monitor for vilazodone adverse effects (nausea, serotonergic symptoms, sedation) and for loss of efficacy, and adjust the vilazodone dose according to response. Counsel patients about drowsiness and driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Other interactions of Stiripentol
Frequently asked questions
Can I take Stiripentol with Vilazodone?
MediHelp rates the interaction as moderate. Stiripentol and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol has both inhibitory and inducing effects on CYP3A4, so vilazodone exposure may rise or fall unpredictably. Both drugs can also cause somnolence, which may be additive.
How serious is the interaction between Stiripentol and Vilazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for vilazodone adverse effects (nausea, serotonergic symptoms, sedation) and for loss of efficacy, and adjust the vilazodone dose according to response. Counsel patients about drowsiness and driving.
What other medicines interact with Vilazodone?
MediHelp also lists interactions of Vilazodone with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Vilazodone page.
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