Drug interactions
Sucralfate + Vitamin d
Severity: Moderate
Sucralfate and Vitamin d: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sucralfate contains aluminum, and vitamin D and its analogs can increase intestinal aluminum absorption. In patients with reduced kidney function, this may lead to aluminum accumulation and toxicity such as bone disease and neurotoxicity. Risk is mainly with long-term use or renal impairment.
What this interaction means in plain words
Sucralfate and Vitamin d can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sucralfate belongs to Gastrointestinal Tract; Vitamin d belongs to Gastrointestinal Tract.
Why it happens
Vitamin D enhances intestinal absorption of aluminum released from sucralfate.
What to do
Avoid prolonged co-use in patients with renal impairment or on dialysis. If needed, limit sucralfate duration and monitor serum aluminum.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sucralfate
Other interactions of Vitamin d
Frequently asked questions
Can I take Sucralfate with Vitamin d?
MediHelp rates the interaction as moderate. Sucralfate and Vitamin d can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sucralfate contains aluminum, and vitamin D and its analogs can increase intestinal aluminum absorption. In patients with reduced kidney function, this may lead to aluminum accumulation and toxicity such as bone disease and neurotoxicity. Risk is mainly with long-term use or renal impairment.
How serious is the interaction between Sucralfate and Vitamin d?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid prolonged co-use in patients with renal impairment or on dialysis. If needed, limit sucralfate duration and monitor serum aluminum.
What other medicines interact with Sucralfate?
MediHelp also lists interactions of Sucralfate with, for example, Ciprofloxacin, Gemifloxacin, Levofloxacin. The full list is on the Sucralfate page.
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