Drug interactions
Tafamidis + Tenofovir alafenamide
Severity: Minor
Tafamidis and Tenofovir alafenamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tafamidis inhibits BCRP in vitro and could increase exposure to BCRP substrates. Any increase in tenofovir alafenamide absorption is likely small.
What this interaction means in plain words
Tafamidis and Tenofovir alafenamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Tafamidis belongs to Cardiovascular; Tenofovir alafenamide belongs to Anti Virals.
Why it happens
Tafamidis inhibits BCRP-mediated efflux of tenofovir alafenamide.
What to do
No empiric dose change is required. Monitor renal function and tenofovir tolerability.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tenofovir alafenamide
- Apalutamide + Tenofovir alafenamide Major
- Berotralstat + Tenofovir alafenamide Moderate
- Danicopan + Tenofovir alafenamide Moderate
- Ifosfamide + Tenofovir alafenamide Moderate
- Orlistat + Tenofovir alafenamide Moderate
- Sotorasib + Tenofovir alafenamide Moderate
Other interactions of Tafamidis
- Apixaban + Tafamidis Moderate
- Atorvastatin + Tafamidis Moderate
- Methotrexate + Tafamidis Moderate
- Mitoxantrone + Tafamidis Moderate
- Pitavastatin + Tafamidis Moderate
- Rivaroxaban + Tafamidis Moderate
Frequently asked questions
Can I take Tafamidis with Tenofovir alafenamide?
MediHelp rates the interaction as minor. Tafamidis and Tenofovir alafenamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tafamidis inhibits BCRP in vitro and could increase exposure to BCRP substrates. Any increase in tenofovir alafenamide absorption is likely small.
How serious is the interaction between Tafamidis and Tenofovir alafenamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric dose change is required. Monitor renal function and tenofovir tolerability.
What other medicines interact with Tenofovir alafenamide?
MediHelp also lists interactions of Tenofovir alafenamide with, for example, Apalutamide, Berotralstat, Danicopan. The full list is on the Tenofovir alafenamide page.
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