Drug interactions
Tedizolid + Vilazodone
Severity: Major
Tedizolid and Vilazodone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilazodone is an SSRI and partial 5-HT1A agonist, and tedizolid is a weak MAO inhibitor. The combination may increase the risk of serotonin syndrome. Direct clinical data are scarce.
What this interaction means in plain words
Tedizolid and Vilazodone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Tedizolid belongs to Anti Bacterial; Vilazodone belongs to Central Nervous System.
Why it happens
Additive serotonergic effects from reuptake inhibition plus 5-HT1A agonism and weak MAO inhibition.
What to do
Prefer a non-serotonergic antibiotic. If unavoidable, monitor for serotonin syndrome and stop one drug if symptoms arise.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tedizolid
- Bupropion + Tedizolid Major
- Cyproheptadine + Tedizolid Major
- Deferiprone + Tedizolid Major
- Isocarboxazid + Tedizolid Major
- Meperidine + Tedizolid Major
- Methamphetamine + Tedizolid Major
Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Frequently asked questions
Can I take Tedizolid with Vilazodone?
MediHelp rates the interaction as major. Tedizolid and Vilazodone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vilazodone is an SSRI and partial 5-HT1A agonist, and tedizolid is a weak MAO inhibitor. The combination may increase the risk of serotonin syndrome. Direct clinical data are scarce.
How serious is the interaction between Tedizolid and Vilazodone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-serotonergic antibiotic. If unavoidable, monitor for serotonin syndrome and stop one drug if symptoms arise.
What other medicines interact with Tedizolid?
MediHelp also lists interactions of Tedizolid with, for example, Bupropion, Cyproheptadine, Deferiprone. The full list is on the Tedizolid page.
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