Drug interactions
Temsirolimus + Tepotinib
Severity: Moderate
Temsirolimus and Tepotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tepotinib inhibits P-gp and may raise concentrations of P-gp substrates such as temsirolimus. Higher exposure could increase mTOR-related adverse effects.
What this interaction means in plain words
Temsirolimus and Tepotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Temsirolimus belongs to Oncology; Tepotinib belongs to Oncology.
Why it happens
Inhibition of intestinal P-glycoprotein efflux by tepotinib, increasing temsirolimus absorption.
What to do
Monitor for temsirolimus toxicity such as mucositis, cytopenias, hyperglycemia and pneumonitis, and reduce the dose if adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Other interactions of Tepotinib
- Colchicine + Tepotinib Major
- Digoxin + Tepotinib Major
- Tepotinib + Vincristine Major
- Amiodarone + Tepotinib Moderate
- Apixaban + Tepotinib Moderate
- Atorvastatin + Tepotinib Moderate
Frequently asked questions
Can I take Temsirolimus with Tepotinib?
MediHelp rates the interaction as moderate. Temsirolimus and Tepotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tepotinib inhibits P-gp and may raise concentrations of P-gp substrates such as temsirolimus. Higher exposure could increase mTOR-related adverse effects.
How serious is the interaction between Temsirolimus and Tepotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for temsirolimus toxicity such as mucositis, cytopenias, hyperglycemia and pneumonitis, and reduce the dose if adverse effects emerge.
What other medicines interact with Temsirolimus?
MediHelp also lists interactions of Temsirolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Temsirolimus page.
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