Drug interactions
Temsirolimus + Tucatinib
Severity: Major
Temsirolimus and Tucatinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib inhibits CYP3A4 and P-gp, so it may raise temsirolimus and sirolimus concentrations. This could increase mTOR-related toxicities including mucositis, cytopenias, hyperglycemia and infection.
What this interaction means in plain words
Temsirolimus and Tucatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Temsirolimus belongs to Oncology; Tucatinib belongs to Oncology.
Why it happens
Inhibition of CYP3A4 and P-gp by tucatinib, reducing the clearance of temsirolimus.
What to do
Avoid if possible; otherwise monitor closely for temsirolimus toxicity and reduce the dose if adverse effects occur.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Temsirolimus with Tucatinib?
MediHelp rates the interaction as major. Temsirolimus and Tucatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tucatinib inhibits CYP3A4 and P-gp, so it may raise temsirolimus and sirolimus concentrations. This could increase mTOR-related toxicities including mucositis, cytopenias, hyperglycemia and infection.
How serious is the interaction between Temsirolimus and Tucatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise monitor closely for temsirolimus toxicity and reduce the dose if adverse effects occur.
What other medicines interact with Temsirolimus?
MediHelp also lists interactions of Temsirolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Temsirolimus page.
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