Drug interactions
Teriflunomide + Vadadustat
Severity: Moderate
Teriflunomide and Vadadustat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Teriflunomide may increase vadadustat exposure, which could cause an excessive or rapid hemoglobin rise and raise the risk of thrombotic events and hypertension.
What this interaction means in plain words
Teriflunomide and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Teriflunomide belongs to Central Nervous System; Vadadustat belongs to Endocrine.
Why it happens
Inhibition of renal OAT1/OAT3 transporters by teriflunomide reduces vadadustat clearance.
What to do
Monitor hemoglobin closely and reduce or interrupt the vadadustat dose if hemoglobin rises too quickly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Teriflunomide
Other interactions of Vadadustat
- Atorvastatin + Vadadustat Moderate
- Balsalazide + Vadadustat Moderate
- Baricitinib + Vadadustat Moderate
- Benzathine penicillin g + Vadadustat Moderate
- Calcium carbonate + Vadadustat Moderate
- Calcium + Vadadustat Moderate
Frequently asked questions
Can I take Teriflunomide with Vadadustat?
MediHelp rates the interaction as moderate. Teriflunomide and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Teriflunomide may increase vadadustat exposure, which could cause an excessive or rapid hemoglobin rise and raise the risk of thrombotic events and hypertension.
How serious is the interaction between Teriflunomide and Vadadustat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hemoglobin closely and reduce or interrupt the vadadustat dose if hemoglobin rises too quickly.
What other medicines interact with Teriflunomide?
MediHelp also lists interactions of Teriflunomide with, for example, Ifosfamide, Lomustine, Amiodarone. The full list is on the Teriflunomide page.
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