Drug interactions
Ticlopidine + Vortioxetine
Severity: Moderate
Ticlopidine and Vortioxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vortioxetine, like other serotonergic antidepressants, can impair platelet serotonin uptake and modestly raise bleeding risk. Combined with the antiplatelet effect of ticlopidine, bleeding such as GI or bruising may be more likely.
What this interaction means in plain words
Ticlopidine and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ticlopidine belongs to Cardiovascular; Vortioxetine belongs to Central Nervous System.
Why it happens
Additive effects on platelet function: ticlopidine blocks P2Y12 while vortioxetine reduces platelet serotonin uptake.
What to do
Monitor for signs of bleeding, particularly GI bleeding, and consider gastroprotection in high-risk patients. Reassess the need for both drugs if bleeding occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ticlopidine
Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Frequently asked questions
Can I take Ticlopidine with Vortioxetine?
MediHelp rates the interaction as moderate. Ticlopidine and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vortioxetine, like other serotonergic antidepressants, can impair platelet serotonin uptake and modestly raise bleeding risk. Combined with the antiplatelet effect of ticlopidine, bleeding such as GI or bruising may be more likely.
How serious is the interaction between Ticlopidine and Vortioxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding, particularly GI bleeding, and consider gastroprotection in high-risk patients. Reassess the need for both drugs if bleeding occurs.
What other medicines interact with Ticlopidine?
MediHelp also lists interactions of Ticlopidine with, for example, Mavacamten, Abrocitinib, Acetylsalicylic acid. The full list is on the Ticlopidine page.
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