Drug interactions
Tucatinib + Zonisamide
Severity: Moderate
Tucatinib and Zonisamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib inhibits CYP3A4 and may increase exposure to zonisamide. This could amplify somnolence, dizziness, cognitive effects and other adverse reactions of zonisamide.
What this interaction means in plain words
Tucatinib and Zonisamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tucatinib belongs to Oncology; Zonisamide belongs to Central Nervous System.
Why it happens
Tucatinib inhibits CYP3A4, reducing the metabolic clearance of zonisamide.
What to do
Monitor for zonisamide adverse effects and reduce the dose if they occur. Reassess dosing when tucatinib is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zonisamide
- Zonisamide + Zuranolone Major
- Acetazolamide + Zonisamide Moderate
- Amisulpride + Zonisamide Moderate
- Amobarbital + Zonisamide Moderate
- Apalutamide + Zonisamide Moderate
- Asenapine transdermal + Zonisamide Moderate
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Tucatinib with Zonisamide?
MediHelp rates the interaction as moderate. Tucatinib and Zonisamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tucatinib inhibits CYP3A4 and may increase exposure to zonisamide. This could amplify somnolence, dizziness, cognitive effects and other adverse reactions of zonisamide.
How serious is the interaction between Tucatinib and Zonisamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for zonisamide adverse effects and reduce the dose if they occur. Reassess dosing when tucatinib is stopped.
What other medicines interact with Zonisamide?
MediHelp also lists interactions of Zonisamide with, for example, Zuranolone, Acetazolamide, Amisulpride. The full list is on the Zonisamide page.
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