藥物交互作用
Domperidone + Omeprazole
嚴重程度: 輕微
Domperidone and Omeprazole: minor interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Reduced gastric acidity from omeprazole may lower the absorption of domperidone, which needs an acidic environment for dissolution. This may reduce the prokinetic or antiemetic effect. The clinical impact is usually modest, and omeprazole does not meaningfully inhibit CYP3A4 or add to QT risk.
用白話說明這項交互作用的意義
Domperidone and Omeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Domperidone belongs to Gastrointestinal Tract; Omeprazole belongs to Gastrointestinal Tract.
為什麼會發生
Higher gastric pH from proton pump inhibition reduces domperidone dissolution and absorption. It is not mediated through CYP3A4.
處置方式
Give domperidone 15 to 30 minutes before meals as labelled. Review clinical response and adjust therapy if efficacy is reduced.
可向藥師詢問的問題
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
參考資料
- Motilium (domperidone) Summary of Product Characteristics — EMA SmPC
Domperidone 的其他交互作用
Omeprazole 的其他交互作用
常見問題
Can I take Domperidone with Omeprazole?
MediHelp rates the interaction as minor. Domperidone and Omeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Reduced gastric acidity from omeprazole may lower the absorption of domperidone, which needs an acidic environment for dissolution. This may reduce the prokinetic or antiemetic effect. The clinical impact is usually modest, and omeprazole does not meaningfully inhibit CYP3A4 or add to QT risk.
How serious is the interaction between Domperidone and Omeprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give domperidone 15 to 30 minutes before meals as labelled. Review clinical response and adjust therapy if efficacy is reduced.
What other medicines interact with Domperidone?
MediHelp also lists interactions of Domperidone with, for example, Azithromycin, Erythromycin, Dexlansoprazole. The full list is on the Domperidone page.
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