藥物交互作用
Ampicillin-sulbactam + Omadacycline
嚴重程度: 中度
Ampicillin-sulbactam and Omadacycline: moderate interaction.
最後更新
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摘要
Bacteriostatic tetracyclines have been theorized to blunt the killing activity of beta-lactams, which depend on actively dividing bacteria. Clinical evidence of reduced outcomes is limited and mostly derived from older studies and in vitro data. The concern is greatest in severe infections such as meningitis or endocarditis.
用白話說明這項交互作用的意義
Ampicillin-sulbactam and Omadacycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ampicillin-sulbactam belongs to Anti Bacterial; Omadacycline belongs to Anti Bacterial.
為什麼會發生
Pharmacodynamic antagonism: a bacteriostatic protein synthesis inhibitor slows bacterial growth, reducing the activity of cell-wall-active bactericidal beta-lactams.
處置方式
Avoid combining when treating severe infections that need bactericidal therapy, and choose a single appropriate agent where possible. If both are required, monitor clinical response closely.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Ampicillin-sulbactam 的其他交互作用
Omadacycline 的其他交互作用
常見問題
Can I take Ampicillin-sulbactam with Omadacycline?
MediHelp rates the interaction as moderate. Ampicillin-sulbactam and Omadacycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bacteriostatic tetracyclines have been theorized to blunt the killing activity of beta-lactams, which depend on actively dividing bacteria. Clinical evidence of reduced outcomes is limited and mostly derived from older studies and in vitro data. The concern is greatest in severe infections such as meningitis or endocarditis.
How serious is the interaction between Ampicillin-sulbactam and Omadacycline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining when treating severe infections that need bactericidal therapy, and choose a single appropriate agent where possible. If both are required, monitor clinical response closely.
What other medicines interact with Ampicillin-sulbactam?
MediHelp also lists interactions of Ampicillin-sulbactam with, for example, Methotrexate, Allopurinol, Bcg vaccine live. The full list is on the Ampicillin-sulbactam page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
