藥物交互作用
Avatrombopag + Mifepristone
嚴重程度: 中度
Avatrombopag and Mifepristone: moderate interaction.
最後更新
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摘要
Mifepristone inhibits CYP3A4 and may increase avatrombopag exposure. This can enhance platelet count elevation and raise the risk of thromboembolic events.
用白話說明這項交互作用的意義
Avatrombopag and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avatrombopag belongs to Miscellaneous; Mifepristone belongs to Endocrine.
為什麼會發生
Inhibition of CYP3A4 (with CYP2C9 contribution) metabolism of avatrombopag by mifepristone.
處置方式
Use a reduced avatrombopag starting dose when treating ITP, as per labeling. Monitor platelet counts and adjust the dose when mifepristone is started or stopped.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Mifepristone 的其他交互作用
Avatrombopag 的其他交互作用
常見問題
Can I take Avatrombopag with Mifepristone?
MediHelp rates the interaction as moderate. Avatrombopag and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone inhibits CYP3A4 and may increase avatrombopag exposure. This can enhance platelet count elevation and raise the risk of thromboembolic events.
How serious is the interaction between Avatrombopag and Mifepristone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a reduced avatrombopag starting dose when treating ITP, as per labeling. Monitor platelet counts and adjust the dose when mifepristone is started or stopped.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
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