藥物交互作用
Bosutinib + Nizatidine
嚴重程度: 中度
Bosutinib and Nizatidine: moderate interaction.
最後更新
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摘要
Bosutinib solubility falls as gastric pH rises, so acid-reducing agents can lower its absorption. This may reduce efficacy in leukemia treatment.
用白話說明這項交互作用的意義
Bosutinib and Nizatidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosutinib belongs to Oncology; Nizatidine belongs to Gastrointestinal Tract.
為什麼會發生
Nizatidine increases gastric pH, reducing pH-dependent dissolution and absorption of bosutinib.
處置方式
Consider short-acting antacids separated from bosutinib by at least 2 hours, or an alternative to the H2 blocker.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Nizatidine 的其他交互作用
Bosutinib 的其他交互作用
常見問題
Can I take Bosutinib with Nizatidine?
MediHelp rates the interaction as moderate. Bosutinib and Nizatidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosutinib solubility falls as gastric pH rises, so acid-reducing agents can lower its absorption. This may reduce efficacy in leukemia treatment.
How serious is the interaction between Bosutinib and Nizatidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider short-acting antacids separated from bosutinib by at least 2 hours, or an alternative to the H2 blocker.
What other medicines interact with Nizatidine?
MediHelp also lists interactions of Nizatidine with, for example, Atazanavir, Dasatinib, Erlotinib. The full list is on the Nizatidine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
