藥物交互作用
Bupropion + Cefpirome
嚴重程度: 中度
Bupropion and Cefpirome: moderate interaction.
最後更新
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摘要
Cefepime-class cephalosporins such as cefpirome can cause neurotoxicity and lower the seizure threshold, particularly in renal impairment. Together with bupropion, which also lowers the seizure threshold, the risk of seizures may be increased.
用白話說明這項交互作用的意義
Bupropion and Cefpirome can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bupropion belongs to Central Nervous System; Cefpirome belongs to Anti Bacterial.
為什麼會發生
Additive lowering of seizure threshold (cephalosporin GABA-A antagonism plus bupropion's proconvulsant effect).
處置方式
Keep the bupropion dose as low as possible and adjust cefpirome dose for renal function. Monitor for myoclonus, confusion or seizures.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Bupropion 的其他交互作用
Cefpirome 的其他交互作用
常見問題
Can I take Bupropion with Cefpirome?
MediHelp rates the interaction as moderate. Bupropion and Cefpirome can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cefepime-class cephalosporins such as cefpirome can cause neurotoxicity and lower the seizure threshold, particularly in renal impairment. Together with bupropion, which also lowers the seizure threshold, the risk of seizures may be increased.
How serious is the interaction between Bupropion and Cefpirome?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep the bupropion dose as low as possible and adjust cefpirome dose for renal function. Monitor for myoclonus, confusion or seizures.
What other medicines interact with Bupropion?
MediHelp also lists interactions of Bupropion with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Bupropion page.
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