藥物交互作用
Bupropion-naltrexone + Cefpirome
嚴重程度: 中度
Bupropion-naltrexone and Cefpirome: moderate interaction.
最後更新
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摘要
Cephalosporins such as cefpirome can lower the seizure threshold, especially in renal impairment. Combined with bupropion, which is itself dose-dependently epileptogenic, seizure risk may rise.
用白話說明這項交互作用的意義
Bupropion-naltrexone and Cefpirome can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bupropion-naltrexone belongs to Miscellaneous; Cefpirome belongs to Anti Bacterial.
為什麼會發生
Additive lowering of seizure threshold through pharmacodynamic effects.
處置方式
Adjust cefpirome dose to renal function and avoid exceeding the lowest effective bupropion dose. Monitor for neurological symptoms.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Bupropion-naltrexone 的其他交互作用
Cefpirome 的其他交互作用
常見問題
Can I take Bupropion-naltrexone with Cefpirome?
MediHelp rates the interaction as moderate. Bupropion-naltrexone and Cefpirome can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cephalosporins such as cefpirome can lower the seizure threshold, especially in renal impairment. Combined with bupropion, which is itself dose-dependently epileptogenic, seizure risk may rise.
How serious is the interaction between Bupropion-naltrexone and Cefpirome?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Adjust cefpirome dose to renal function and avoid exceeding the lowest effective bupropion dose. Monitor for neurological symptoms.
What other medicines interact with Bupropion-naltrexone?
MediHelp also lists interactions of Bupropion-naltrexone with, for example, Hydrocodone, Hydromorphone, Isocarboxazid. The full list is on the Bupropion-naltrexone page.
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