藥物交互作用
Eluxadoline + Meperidine
嚴重程度: 嚴重
Eluxadoline and Meperidine: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Eluxadoline is a mu-opioid receptor agonist used for diarrhea-predominant IBS, and opioids such as meperidine slow gut transit. Together they raise the risk of severe constipation and related complications such as ileus or pancreatitis-related events.
用白話說明這項交互作用的意義
Eluxadoline and Meperidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eluxadoline belongs to Gastrointestinal Tract; Meperidine belongs to Musculoskeletal.
為什麼會發生
Additive opioid receptor-mediated reduction of gastrointestinal motility.
處置方式
Avoid concomitant use; if an opioid is needed, stop eluxadoline and monitor bowel function closely.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Meperidine 的其他交互作用
Eluxadoline 的其他交互作用
常見問題
Can I take Eluxadoline with Meperidine?
MediHelp rates the interaction as major. Eluxadoline and Meperidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Eluxadoline is a mu-opioid receptor agonist used for diarrhea-predominant IBS, and opioids such as meperidine slow gut transit. Together they raise the risk of severe constipation and related complications such as ileus or pancreatitis-related events.
How serious is the interaction between Eluxadoline and Meperidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use; if an opioid is needed, stop eluxadoline and monitor bowel function closely.
What other medicines interact with Meperidine?
MediHelp also lists interactions of Meperidine with, for example, Alvimopan, Isocarboxazid, Methylene blue. The full list is on the Meperidine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
