藥物交互作用
Ketoconazole + Rifaximin
嚴重程度: 中度
Ketoconazole and Rifaximin: moderate interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Ketoconazole inhibits P-glycoprotein and may increase absorbed rifaximin. Because baseline systemic exposure is very low, the impact is usually small but could matter in severe hepatic dysfunction.
用白話說明這項交互作用的意義
Ketoconazole and Rifaximin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketoconazole belongs to Anti Fungals; Rifaximin belongs to Anti Bacterial.
為什麼會發生
P-glycoprotein inhibition by ketoconazole decreases rifaximin efflux.
處置方式
Monitor for rifaximin adverse effects and avoid dose escalation, particularly in hepatic impairment.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Rifaximin 的其他交互作用
Ketoconazole 的其他交互作用
常見問題
Can I take Ketoconazole with Rifaximin?
MediHelp rates the interaction as moderate. Ketoconazole and Rifaximin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketoconazole inhibits P-glycoprotein and may increase absorbed rifaximin. Because baseline systemic exposure is very low, the impact is usually small but could matter in severe hepatic dysfunction.
How serious is the interaction between Ketoconazole and Rifaximin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for rifaximin adverse effects and avoid dose escalation, particularly in hepatic impairment.
What other medicines interact with Rifaximin?
MediHelp also lists interactions of Rifaximin with, for example, Cholera vaccine, Microbiota, Amiodarone. The full list is on the Rifaximin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
