藥物交互作用
Lidocaine + Pefloxacin
嚴重程度: 中度
Lidocaine and Pefloxacin: moderate interaction.
最後更新
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摘要
Fluoroquinolones that inhibit CYP1A2 can reduce lidocaine clearance and raise its concentrations. Pefloxacin is a CYP1A2 inhibitor and this may lead to lidocaine toxicity with systemic or repeated dosing.
用白話說明這項交互作用的意義
Lidocaine and Pefloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lidocaine belongs to Cardiovascular; Pefloxacin belongs to Anti Bacterial.
為什麼會發生
Inhibition of CYP1A2-mediated lidocaine metabolism reduces clearance.
處置方式
With systemic lidocaine infusion, monitor for signs of toxicity and consider dose reduction; no change is usually needed for single local anesthetic doses.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Lidocaine 的其他交互作用
Pefloxacin 的其他交互作用
常見問題
Can I take Lidocaine with Pefloxacin?
MediHelp rates the interaction as moderate. Lidocaine and Pefloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoroquinolones that inhibit CYP1A2 can reduce lidocaine clearance and raise its concentrations. Pefloxacin is a CYP1A2 inhibitor and this may lead to lidocaine toxicity with systemic or repeated dosing.
How serious is the interaction between Lidocaine and Pefloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: With systemic lidocaine infusion, monitor for signs of toxicity and consider dose reduction; no change is usually needed for single local anesthetic doses.
What other medicines interact with Lidocaine?
MediHelp also lists interactions of Lidocaine with, for example, Bupivacaine liposome, Disopyramide, Ex vivo expanded autologous human corneal epithelial cells containing stem cells. The full list is on the Lidocaine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
