Drug interactions
Aminolevulinic acid + Prochlorperazine
Severity: Moderate
Aminolevulinic acid and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prochlorperazine, a phenothiazine, can cause photosensitivity, which may add to the phototoxic reaction caused by oral aminolevulinic acid. This increases the risk of skin and eye injury on light exposure.
What this interaction means in plain words
Aminolevulinic acid and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aminolevulinic acid belongs to Miscellaneous; Prochlorperazine belongs to Central Nervous System.
Why it happens
Additive photosensitizing effects of two phototoxic agents.
What to do
Avoid other photosensitizing drugs for the period specified in the aminolevulinic acid labeling and instruct the patient to avoid sunlight and bright indoor light.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Aminolevulinic acid
- Acitretin + Aminolevulinic acid Major
- Aminolevulinic acid + Doxycycline Major
- Aminolevulinic acid + Isotretinoin Major
- Aminolevulinic acid + Amiodarone Moderate
- Aminolevulinic acid + Amlodipine-hydrochlorothiazide-valsartan Moderate
- Aminolevulinic acid + Amlodipine-olmesartan-hydrochlorothiazide Moderate
Frequently asked questions
Can I take Aminolevulinic acid with Prochlorperazine?
MediHelp rates the interaction as moderate. Aminolevulinic acid and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Prochlorperazine, a phenothiazine, can cause photosensitivity, which may add to the phototoxic reaction caused by oral aminolevulinic acid. This increases the risk of skin and eye injury on light exposure.
How serious is the interaction between Aminolevulinic acid and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid other photosensitizing drugs for the period specified in the aminolevulinic acid labeling and instruct the patient to avoid sunlight and bright indoor light.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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