Drug interactions
Amisulpride + Pentamidine
Severity: Major
Amisulpride and Pentamidine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic pentamidine is associated with QT prolongation and torsades de pointes, and amisulpride adds to this effect. The combination can lead to life-threatening arrhythmia, especially with electrolyte disturbances.
What this interaction means in plain words
Amisulpride and Pentamidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amisulpride belongs to Central Nervous System; Pentamidine belongs to Anti Parasitic.
Why it happens
Additive QT prolongation through delayed cardiac repolarization.
What to do
Avoid concurrent use where possible, or withhold amisulpride during pentamidine therapy. If unavoidable, monitor ECG and correct potassium and magnesium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
Other interactions of Pentamidine
- Clomipramine + Pentamidine Contraindicated
- Desipramine + Pentamidine Contraindicated
- Dronedarone + Pentamidine Contraindicated
- Moxifloxacin + Pentamidine Contraindicated
- Nortriptyline + Pentamidine Contraindicated
- Pentamidine + Pimozide Contraindicated
Frequently asked questions
Can I take Amisulpride with Pentamidine?
MediHelp rates the interaction as major. Amisulpride and Pentamidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Systemic pentamidine is associated with QT prolongation and torsades de pointes, and amisulpride adds to this effect. The combination can lead to life-threatening arrhythmia, especially with electrolyte disturbances.
How serious is the interaction between Amisulpride and Pentamidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible, or withhold amisulpride during pentamidine therapy. If unavoidable, monitor ECG and correct potassium and magnesium.
What other medicines interact with Amisulpride?
MediHelp also lists interactions of Amisulpride with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Amisulpride page.
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